Identification of H2N3 influenza A viruses from swine in the United States
Identifieur interne : 000107 ( 1968/Analysis ); précédent : 000106; suivant : 000108Identification of H2N3 influenza A viruses from swine in the United States
Auteurs : Wenjun Ma [États-Unis] ; Amy L. Vincent [États-Unis] ; Marie R. Gramer [États-Unis] ; Christy B. Brockwell [États-Unis] ; Kelly M. Lager [États-Unis] ; Bruce H. Janke [États-Unis] ; Phillip C. Gauger [États-Unis] ; Devi P. Patnayak [États-Unis] ; Richard J. Webby [États-Unis] ; Jürgen A. Richt [États-Unis]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2007.
Abstract
Although viruses of each of the 16 influenza A HA subtypes are potential human pathogens, only viruses of the H1, H2, and H3 subtype are known to have been successfully established in humans. H2 influenza viruses have been absent from human circulation since 1968, and as such they pose a substantial human pandemic risk. In this report, we isolate and characterize genetically similar avian/swine virus reassortant H2N3 influenza A viruses isolated from diseased swine from two farms in the United States. These viruses contained leucine at position 226 of the H2 protein, which has been associated with increased binding affinity to the mammalian α2,6Gal-linked sialic acid virus receptor. Correspondingly, the H2N3 viruses were able to cause disease in experimentally infected swine and mice without prior adaptation. In addition, the swine H2N3 virus was infectious and highly transmissible in swine and ferrets. Taken together, these findings suggest that the H2N3 virus has undergone some adaptation to the mammalian host and that their spread should be very closely monitored.
Url:
DOI: 10.1073/pnas.0710286104
PubMed: 18093945
PubMed Central: 2409247
Affiliations:
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PMC:2409247Le document en format XML
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Gramer</name><affiliation wicri:level="2"><nlm:aff id="aff3">Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Minnesota, St. Paul</wicri:cityArea></affiliation></author><author><name sortKey="Brockwell, Christy B" sort="Brockwell, Christy B" uniqKey="Brockwell C" first="Christy B." last="Brockwell">Christy B. Brockwell</name><affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff4">St. Jude Children's Research Hospital, Memphis, TN 38018</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>St. Jude Children's Research Hospital, Memphis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff5">Interdisciplinary Program, University of Tennessee Health Science Center, Memphis, TN 38163</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Interdisciplinary Program, University of Tennessee Health Science Center, Memphis</wicri:cityArea></affiliation></author><author><name sortKey="Lager, Kelly M" sort="Lager, Kelly M" uniqKey="Lager K" first="Kelly M." last="Lager">Kelly M. Lager</name><affiliation wicri:level="2"><nlm:aff id="aff2">Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames</wicri:cityArea></affiliation></author><author><name sortKey="Janke, Bruce H" sort="Janke, Bruce H" uniqKey="Janke B" first="Bruce H." last="Janke">Bruce H. Janke</name><affiliation wicri:level="2"><nlm:aff id="aff1">*Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>*Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames</wicri:cityArea></affiliation></author><author><name sortKey="Gauger, Phillip C" sort="Gauger, Phillip C" uniqKey="Gauger P" first="Phillip C." last="Gauger">Phillip C. Gauger</name><affiliation wicri:level="2"><nlm:aff id="aff2">Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames</wicri:cityArea></affiliation></author><author><name sortKey="Patnayak, Devi P" sort="Patnayak, Devi P" uniqKey="Patnayak D" first="Devi P." last="Patnayak">Devi P. Patnayak</name><affiliation wicri:level="2"><nlm:aff id="aff3">Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Minnesota, St. Paul</wicri:cityArea></affiliation></author><author><name sortKey="Webby, Richard J" sort="Webby, Richard J" uniqKey="Webby R" first="Richard J." last="Webby">Richard J. Webby</name><affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff4">St. Jude Children's Research Hospital, Memphis, TN 38018</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>St. Jude Children's Research Hospital, Memphis</wicri:cityArea></affiliation></author><author><name sortKey="Richt, Jurgen A" sort="Richt, Jurgen A" uniqKey="Richt J" first="Jürgen A." last="Richt">Jürgen A. Richt</name><affiliation wicri:level="2"><nlm:aff id="aff2">Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames</wicri:cityArea></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Although viruses of each of the 16 influenza A HA subtypes are potential human pathogens, only viruses of the H1, H2, and H3 subtype are known to have been successfully established in humans. H2 influenza viruses have been absent from human circulation since 1968, and as such they pose a substantial human pandemic risk. In this report, we isolate and characterize genetically similar avian/swine virus reassortant H2N3 influenza A viruses isolated from diseased swine from two farms in the United States. These viruses contained leucine at position 226 of the H2 protein, which has been associated with increased binding affinity to the mammalian α2,6Gal-linked sialic acid virus receptor. Correspondingly, the H2N3 viruses were able to cause disease in experimentally infected swine and mice without prior adaptation. In addition, the swine H2N3 virus was infectious and highly transmissible in swine and ferrets. Taken together, these findings suggest that the H2N3 virus has undergone some adaptation to the mammalian host and that their spread should be very closely monitored.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Iowa</li><li>Minnesota</li><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Iowa"><name sortKey="Ma, Wenjun" sort="Ma, Wenjun" uniqKey="Ma W" first="Wenjun" last="Ma">Wenjun Ma</name></region><name sortKey="Brockwell, Christy B" sort="Brockwell, Christy B" uniqKey="Brockwell C" first="Christy B." last="Brockwell">Christy B. Brockwell</name><name sortKey="Brockwell, Christy B" sort="Brockwell, Christy B" uniqKey="Brockwell C" first="Christy B." last="Brockwell">Christy B. Brockwell</name><name sortKey="Gauger, Phillip C" sort="Gauger, Phillip C" uniqKey="Gauger P" first="Phillip C." last="Gauger">Phillip C. Gauger</name><name sortKey="Gramer, Marie R" sort="Gramer, Marie R" uniqKey="Gramer M" first="Marie R." last="Gramer">Marie R. Gramer</name><name sortKey="Janke, Bruce H" sort="Janke, Bruce H" uniqKey="Janke B" first="Bruce H." last="Janke">Bruce H. Janke</name><name sortKey="Lager, Kelly M" sort="Lager, Kelly M" uniqKey="Lager K" first="Kelly M." last="Lager">Kelly M. Lager</name><name sortKey="Ma, Wenjun" sort="Ma, Wenjun" uniqKey="Ma W" first="Wenjun" last="Ma">Wenjun Ma</name><name sortKey="Patnayak, Devi P" sort="Patnayak, Devi P" uniqKey="Patnayak D" first="Devi P." last="Patnayak">Devi P. Patnayak</name><name sortKey="Richt, Jurgen A" sort="Richt, Jurgen A" uniqKey="Richt J" first="Jürgen A." last="Richt">Jürgen A. Richt</name><name sortKey="Vincent, Amy L" sort="Vincent, Amy L" uniqKey="Vincent A" first="Amy L." last="Vincent">Amy L. Vincent</name><name sortKey="Webby, Richard J" sort="Webby, Richard J" uniqKey="Webby R" first="Richard J." last="Webby">Richard J. 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